Antifungal and Cytotoxic Activities of Biosynthesized Silver, Zinc and Gold Nanoparticles by Flower Extract of <i>Rhanterium epapposum</i>

• 作者: Mahmoud Sayed Mohammed S. J. Al Qhtani Samah A. El-Debaiky
• 来源期刊: 应用科学(英文)
• 学科: 医学
• 关键词: Nanoparticles Rhanterium epapposum BIOSYNTHESIS ANTIFUNGAL Cytotoxicity
• 年，卷（期）: 2020,（11）
• 页码范围: 663-674
• 页数: 12页
• 分类号: R73

摘要

This study was designed to prepare silver, zinc and gold nanoparticles (NPs), AgNPs, ZnNPs and AuNPs, by biosynthesis technique using methanolic extract of </span><i><span style="font-family:Verdana;">Rhanterium</span></i><span style="font-family:Verdana;"> <i>epapposum</i></span><span style="font-family:Verdana;"> flowers using AgNO</span>_{<span style="font-family:Verdana;">3</span>}<span style="font-family:Verdana;">, Zn (CH</span>_{<span style="font-family:Verdana;">3</span>}<span style="font-family:Verdana;">CO</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">)</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;"> and HAuCl</span>_{<span style="font-family:Verdana;">4</span>}<span style="font-family:Verdana;">·3H</span>_{<span style="font-family:Verdana;">2</span>}<span style="font-family:Verdana;">O as starting materials. The physical properties of the formed NPs were characterized by ultraviolet spectroscopy (UV), X-ray diffraction (XRD), transmission electron microscopy and Fourier transformed infrared spectroscopy (FTIR). The results revealed that, AgNPs were homogeneous and spherical in shape, with average diameter 16.3 nm. While, ZnNPs were approximately triangle and hexagonal shaped, with average diameter 23.5 nm. Most of the synthesized AuNPs were spherical in shape with average diameter 17.9 nm. The antifungal activity of different concentrations of the formed AgNPs, ZnNPs and AuNPs was tested against two human </span></span><span style="font-family:Verdana;">pathogens</span><span style="font-family:Verdana;">:</span><span style="font-family:""> </span><i><span style="font-family:Verdana;">Candida albicans</span></i><span style="font-family:""><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">Aspergillus</span></i><span style="font-family:Verdana;"> <i>melleus</i></span><span style="font-family:Verdana;"> and one plant pathogenic fungus</span></s