Antioxidant and Antiplasmodial Activities of Extracts from <i>Gardenia erubescens</i>Stapf et Hutch. and <i>Fadogia agrestis</i>Schweinf. ex Hiern. (Rubiaceae)

• 作者: Anne-Flora Drabo Assetou Sawadogo Benjamin Koama George Anicet Ouédraogo Hadidjatou Belem Mariama Kaba Combasséré-Chérif Roland Nâg-Tiéro Meda Sandrine Nadège Da Windmi Kagambéga
• 来源期刊: 应用科学(英文)
• 学科: 医学
• 关键词: Antiplasmodial Activity Antioxidant Activity Gardenia erubescens Fadogia agrestis
• 年，卷（期）: 2020,（11）
• 页码范围: 675-687
• 页数: 13页
• 分类号: R28

摘要

Two medicinal plants,<span> <i><span style="font-family:Verdana;">Gardenia</span></i> <i><span style="font-family:Verdana;">erubescens</span></i></span><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">Fadogia</span></i><span style="font-family:Verdana;"> <i>agrestis</i></span><span style="font-family:Verdana;"> were selected</span><span style="font-family:;" "=""> <span style="font-family:Verdana;">to evaluate their biological activities. Their total phenolic and flavonoid contents</span> <span style="font-family:Verdana;">were assessed using folin-ciocalteu and aluminum chloride regents’ methods. The antioxidant activity was estimated using DPPH (1,1-diphényl-2-picrylhydrazyl),</span><span> </span><span style="font-family:Verdana;">ABTS (</span></span><span style="font-family:Verdana;">2,2’-azinobis-[3-ethylenzothiazoline-6-sulfonic acid]</span><span style="font-family:Verdana;">) and FRAP (ferric reducing antioxidant power). The antiplasmodial activity of the extracts</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> was determined </span><i><span style="font-family:Verdana;">in</span></i> <i><span style="font-family:Verdana;">vivo</span></i><span style="font-family:Verdana;"> on 42 NMRI mice. The results indicate that all the extracts from both two plants contain some polyphenols. The ethanolic extract of the leaves of </span><i><span style="font-family:Verdana;">Gardenia</span></i> <i><span style="font-family:Verdana;">erubescens</span></i><span style="font-family:Verdana;"> showed the best antioxidant activity by the method of DPPH. The aqueous extracts of the leaves of </span><i><span style="font-family:Verdana;">Gardenia</span></i> <i><span style="font-family:Verdana;">erubescens</span></i><span style="font-family:Verdana;"> and the whole plant of </span><i><span style="font-family:Verdana;">Fadogia</span></i> <i><span style="font-family:Verdana;">agrestis</span></i><span style="font-family:Verdana;"> have a reducing power similar to control