Prion Protein Expression is Correlated with Glioma Grades

• 作者: Dongying Fan Jing An Peigang Wang Qiaoli Luo Shijie Wang Yisong Wang
• 来源期刊: 中国病毒学
• 年，卷（期）: 2020,（4）
• 所属期刊栏目: LETTERS
• 页码范围: 490-493
• 页数: 4页
• 语种: 英文

摘要

Dear Editor, Glioma is the most common primary central nervous system (CNS) tumors in human.Gliomas are classified into low-grade glioma (LGG, grades Ⅰ-Ⅱ) and high-grade glioma (HGG, grades Ⅲ-ⅣV) according to the World Health Organization classification guidelines (Louis et al.2007).Comparing to the LGG, the HGG becomes more aggressive and has a poorer median overall survival.At present, glioma is mainly treated by radiotherapy, chemotherapy and surgical resection, but the effect is not ideal, especially for the glioblastoma (GBM), which is the most malignant type of gliomas and is resistant to current therapy protocols.There are several theories about the pathogenesis of glioma, such as radiation (Ohgaki and Kleihues 2005), genetics (Farrell and Plotkin 2007;Goodenberger and Jenkins 2012) and viruses (Lawler.2015;Xing et al.2016), while its etiology remains obscure.