The Clinical Features and Outcomes of Four Neonates Born to Mothers with a Severe Form of COVID-19 and a Positive RT-PCR for SARS Co-V2 in Douala Gynaeco-Obstetric and Pediatric Hospital in Cameroon

• 作者: A. Ngalame C. Mbakop Tchogna D. Djomo Tamchom D. Kamdem D. Mwadjie D. Noukeu Njinkui Dominique Enyama E. T. Mboudou F. Kemta Lekpa G. P. Ngaba H. Neng I. Rakya M. C. Bissa Ndongo Eteme R. Tiokeng Nenzeko S. P. Choukem S. R. Simeni Njonnou S. R. Wekang Tcheuffa
• 来源期刊: 儿科学期刊(英文)
• 学科: 医学
• 关键词: COVID-19 Infected Mothers Premature Newborns Severe Respiratory Distress Outcome Cameroon
• 年，卷（期）: 2020,（4）
• 页码范围: 642-651
• 页数: 10页
• 分类号: R72

摘要

<strong>Ba</strong><span style="font-family:Verdana;"><strong>ckground:</strong></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> A novel viral respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for a worldwide pandemic. The effects of this new disease in pregnant women and newborns are actually not well known. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We investigated the clinical features and outcomes of four neonates born to mothers with a s</span></span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">evere form of COVID-19 and a positive RT-PCR for SARS Co-V2 in Douala Gynaeco-Obstetric and Pediatric Hospital (Cameroon) from April 20 to June 5, 2020. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> All four mothers were symptomatic and had a positive RT-PCR for SARS CoV-2 from nasopharyngeal swab on admission. All of them delivered prematurely through cesarean section because of severe respiratory distress and one died shortly after delivery. The four premature male infants were born between 30 weeks and 35 weeks 2 days of gestation and had birth weights ranging from 1090 g to 2950 g. All infants had 1-minute Apgar scores that ranged from 7 to 8 and 5-minute Apgar scores varying between 8 and 9. They were isolated from their mothers immediately after birth and received formula feeding. Three of the four infants were tested using nasopharyngeal swab specimens for RT-PCR 24 to 48 hours after birth and were negative for COVID-19. All the infants were treated in a dedicated area at the neonatal care unit and presented with mild respiratory distress on admission with a Silverman score that varied between 2 and 4/10. During their hospitalization, all the infants also presented with jaundice and underwent phototherapy. Three of them had anemia with hemoglobin levels ranging from