Proteome-wide data analysis reveals tissue-specific network associated with SARS-CoV-2 infection

• 作者: Li Feng Yuan-Yuan Yin Cong-Hui Liu Ke-Ren Xu Qing-Run Li Jia-Rui Wu Rong Zeng
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Articles
• 页码范围: 946-957
• 页数: 12页
• 语种: 英文
• DOI: 10.1093/jmcb/mjaa033

摘要

For patients with COVID-19 caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the damages to multiple organs have been clinically observed.Since most of current investigations for virus-host interaction are based on cell level,there is an urgent demand to probe tissue-specific features associated with SARS-CoV-2 infection.Based on collected proteomic data-sets from human lung,colon,kidney,liver,and heart,we constructed a virus-receptor network,a virus-interaction network,and a virus-perturbation network.In the tissue-specific networks associated with virus-host crosstalk,both common and different key hubs are revealed in diverse tissues.Ubiquitous hubs in multiple tissues such as BRD4 and RIPK1 would be promising drug tar-gets to rescue multi-organ injury and deal with inflammation.Certain tissue-unique hubs such as REEP5 might mediate specific olfactory dysfunction.The present analysis implies that SARS-CoV-2 could affect multi-targets in diverse host tissues,and the treatment of COVID-19 would be a complex task.