A 'Goldmine' for digging cancer-specific targets:the genes essential for embryo development but non-essential for adult life

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2020,（9）
• 所属期刊栏目: Perspective
• 页码范围: 669-673
• 页数: 5页
• 语种: 英文
• DOI: 10.1093/jmcb/mjaa024

摘要

Cancer initiation and progression are usually triggered by protooncogene acti-vation and/or tumor suppressor gene in-activation and promoted by further genomic and epigenetic alterations that reprogram cell gene expression,metabo-lism,proliferation,differentiation,and behavior.Overexpressed or mutation-activated tyrosine kinase receptors and their signaling components,such as HER2,EGFR,Src,RAS,PI3K,and AKT,ste-roid hormone receptors,such as estro-gen receptor and androgen receptor,and other cell growth and cell cycle regula-tors induce carcinogenesis or promote cancer cell growth,survival,and progres-sion.