Parameter Sensitivity and Qualitative Analysis of Dynamics of Ovarian Tumor Growth Model with Treatment Strategy

• 作者: Md. Kamrujjaman Md. Shafiqul Islam Md. Shah Alam
• 来源期刊: 应用数学与应用物理(英文)
• 学科: 医学
• 关键词: Parameter Sensitivity Latin Hypercube Sampling Partial Rank Correlation Coefficient Scatter Plot MONOTONICITY Stability Analysis
• 年，卷（期）: 2020,（6）
• 页码范围: 941-955
• 页数: 15页
• 分类号: R73

摘要

In this paper, we are interested to find the most sensitive parameter, local and global stability of ovarian tumor growth model. For sensitivity analysis, we use Latin Hypercube Sampling (LHS) method to generate sample points and Partial Rank Correlation Coefficient (PRCC) method, uses those sample points to find out which parameters are important for the model. Based on our findings, we suggest some treatment strategies. We investigate the sensitivity of the parameters for tumor volume, <em>y</em>, cell nutrient density, <em>Q</em> and maximum tumor size, <em>ymax</em>. We also use Scatter Plot method using LHS samples to show the consistency of the results obtained by using PRCC. Moreover, we discuss the qualitative analysis of ovarian tumor growth model investigating the local and global stability.