<strong>Background:</strong><b><i><span style="font-family:""> </span></i></b><span style="font-family:Verdana;">Mechanical ventilation (MV) is one of the most common therapies in the neonatal Intensive Care Unit (NICU) and is associated with increased morbidity and mortality. MV is a complex and highly specialized area in neonatology that has several complications related to different modes, techniques, and devices.</span><span style="font-family:""> </span><b><span style="font-family:Verdana;">Aim of the Study</span></b><b><span style="font-family:Verdana;">:</span></b><b><span style="font-family:""> </span></b><span style="font-family:Verdana;">To detect the causes of morbidity and mortality in mechanically ventilated neonates and to correlate the neonatal morbidity and mortality with gestational age, birth weight and duration of MV.</span><span style="font-family:""> </span><b><span style="font-family:""><span style="font-family:Verdana;">Patients and Methods:</span><i> </i></span></b><span style="font-family:Verdana;">This prospective observation analytical study was carried out on 110 neonates who were admitted to NICU at Al-Zahraa university hospital on MV during the period from March 2019 to March 2020. All neonates were followed up till the time of discharge with record of any complications during mechanical ventilation. Detailed medical history, examination to detect indication of MV and laboratory,</span><span style="font-family:""> </span><span style="font-family:Verdana;">radiological investigations were recorded.</span><span style="font-family:""> </span><span style="font-family:Verdana;">As regard the general characterization of studied neonates, 64 (58.2%) were males while the rest 46 (41.8%) were females, 50 (45.4%) were full term (37</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">42 wks), 42</span><span style="font-family:""> </span><span style="font-family:Verdana;">(38.18%) were early p