Hepatic Protective Effects of <i>S</i>-Allyl-L-Cysteine (SAC) in Rats with Carbon Tetrachloride (CCl<sub>4</sub>) Induced Liver Injury

• 作者: H. M. Arif Ullah Hae-Young Chung Hyun-Ho Yun Il-Hwa Hong Jae-Hyuk Yim Ji-Yoon Son Jin-Kyu Park Kyu-Shik Jeong Myung-Jin Chung Seung-Jun Jung Soo-Nyun Choi SunYoung Park
• 来源期刊: 食品与营养科学(英文)
• 学科: 数学
• 关键词: S-Allyl-L-Cysteine (SAC) Garlic Hepatic Protective Effects Carbon Tetrachloride Rats Hepatic Steatosis Cytochrome P4502E1
• 年，卷（期）: 2020,（12）
• 页码范围: 1053-1069
• 页数: 17页
• 分类号: O17

摘要

<span style="font-family:Verdana;"><i><span style="font-family:Verdana;"><i></span></i></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">S</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;"></i></span></i></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">-allyl-L-cysteine (SAC) is an organosulfur compound derived from aged garlic extract (</span><span style="font-family:Verdana;">AGE</span><span style="font-family:Verdana;">). Studies have reported that AGE possesses bioprotective capacity, including antidiabetic, antimicrobial, antioxidant, and antitumor effects. The present study examined the protective effects of SAC against carbon tetrachloride (CCl</span>_{<span style="font-family:Verdana;">4</span>}<span style="font-family:Verdana;">) induced hepatotoxicity in rats. Ten male Wistar rats aged 11 - 12 weeks were randomly divided into two groups (five rats/group) as control and SAC groups. All rats had </span><span style="font-family:Verdana;">ad</span> <span style="font-family:Verdana;">libitum</span><span style="font-family:Verdana;"> access to water, and the SAC group received water containing SAC intragastrically (200 mg/kg) once daily for five consecutive weeks. In the fifth experimental week, 50% CCl</span>_{<span style="font-family:Verdana;">4</span>}<span style="font-family:Verdana;"> in olive oil (1 mL/kg) was administered intraperitoneally three times a week to induce liver injury in both groups. Rats were sacrificed at 24 hours after the last CCl</span>_{<span style="font-family:Verdana;">4</span>}<span style="font-family:Verdana;"> injection, and liver tissues were excised for histopathological, immunohistochemical and antioxidant analyses. The rats in the SAC group did not show abnormal behavior, such as decreased water intake or food consumption, during the experimental period. Body weights