Organelle remodeling in somatic cell reprogramming

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2020,（10）
• 所属期刊栏目: Perspectives
• 页码范围: 747-751
• 页数: 5页
• 语种: 英文
• DOI: 10.1093/jmcb/mjaa032

摘要

Works based on the generation of in-duced pluripotent stem cells(iPSCs)me-diated by expressing Yamanaka cocktail factors(Takahashi and Yamanaka,2006)have been extensively reported.During somatic cell reprogramming,many organ-elles get remodeled on multilayer such as organelle morphology,metabolic patterns,and meanwhile epigenetic landscapes and gene expression changes.In the pro-cess of organelle plasticity control,lipids,ions,and metabolites are ferried to partic-ular targets.Such reorientations need the aid of membrane trafficking.However,most related mechanisms and physiologi-cal/pathological functions remain largely unknown.