Introduction: <span style="font-family:""><span style="font-family:Verdana;">Some somatic and psychological disorders have been associated with handgrip strength, which is an easy, inexpensive and noninvasive method for assessment of muscle strength. We conducted a cross-sectional </span><span style="font-family:Verdana;">study to clarify the relationship of handgrip strength and menstruation-related </span><span style="font-family:Verdana;">symptoms. </span><b><span style="font-family:Verdana;">Material and Methods:</span></b><span style="font-family:Verdana;"> Handgrip strength was measured and a self-administered questionnaire was performed in female university students in Japan. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">Handgrip strength did not significantly differ among the menstrual phases. The mean handgrip strength level (n = 260) was 26.0 ± 3.9 kg. We divided the subjects into three groups according to the handgrip strength level. Handgrip strength was associated with degrees of depression and anxiety during menstruation.</span><b><span style="font-family:Verdana;"> Conclusion: </span></b><span style="font-family:Verdana;">This can be used as fundamental data in further clarifying the relationship between muscle strength and menstruation-related symptoms.</span></span>