Preliminary Evaluation of Hepatorenal Protective Potentials of <i>Kigelia africana</i>Ethanolic Leaf Extract on Carbon Tetrachloride Induced Toxicity in Adult Male Wistar Rats

• 作者: Dluya Thagriki Ibrahim Malgwi Samaila Nachamada Emmanuel Solomon Neftiya Yaduma Wandiahyel Yaduma Gaiuson
• 来源期刊: 美国植物学期刊(英文)
• 学科: 数学
• 关键词: Kigelia africana PHYTOCHEMICALS HEPATOTOXICITY Renal Toxicity CCl₄
• 年，卷（期）: 2020,（9）
• 页码范围: 1345-1359
• 页数: 15页
• 分类号: O17

摘要

<p style="text-align:justify;"> <i><span style="font-family:Verdana;">Background</span></i><span style="font-family:;" "=""> <i><span style="font-family:Verdana;">and</span></i> <i><span style="font-family:Verdana;">aim</span></i><span style="font-family:Verdana;">: Hepatorenal toxicity is a very common ailment with </span><span style="font-family:Verdana;">resultant</span><span style="font-family:Verdana;"> deleterious burden on the overall body systems and high mortality rate. Although myriads of drug agents are in circulation, its medical management is still inadequate as no effective treatment which inhibits disease progression and </span><span style="font-family:Verdana;">complications,</span> <span style="font-family:Verdana;">has</span><span style="font-family:Verdana;"> been </span><span style="font-family:Verdana;">synthesized</span><span style="font-family:Verdana;"> yet. Therefore, this study focused on the potentials of </span><i><span style="font-family:Verdana;">Kigelia</span></i> <i><span style="font-family:Verdana;">africana</span></i><span style="font-family:Verdana;"> ethanolic leaf extract (KAELE) in preventing hepatorenal toxicity using </span><span><span style="font-family:Verdana;">CCl</span>_{<span style="font-family:Verdana;">4</span>}</span><span style="font-family:Verdana;"> model of toxicity in rats. </span><i><span style="font-family:Verdana;">Method:</span></i><span style="font-family:Verdana;"> KAELE was subjected to phytochemical screening. Following two-week acclimatization, </span><span style="font-family:Verdana;">thirty-six</span><span style="font-family:Verdana;"> (N = 36) adult male Wistar rats were grouped into six consisting of six animals each (n = 6). Group I was given distilled water as control while groups II to VI received silymarin (100 mg/kg), CCl</span>_{<span style="font-family:Verdana;">4</span>}<span style="font-family:Verdana;"> (1 ml/kg), KAELE (100 mg/kg, 200 mg/kg </span><span style="font-family:Verdana;">and</span><span style="font-family:Verd