To survive, animals must process aversive or stressful events quickly, and evaluate and store the related information.Accumulating neural circuity studies have identified key brain nuclei, such as the amygdala, lateral habenula (LHb), periaqueductal grey (PAG), ventromedial hypothalamic nucleus, hippocampus, among others, in the processing of negative experiences [1, 2].Yet more work is needed to determine how these brain structures coordinate with each other in coping with such experiences.