Compound’s Pre-Screening of <i>Withania somnifera</i>, <i>Bacopa monnieri</i>and <i>Centella asiatica</i>Extracts

• 作者: Ago Samoson Georg Arju Maria Kuhtinskaja Marina Junusova Raiker Witter Raivo Vilu Steffi Witter
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: Gas Chromatography-Mass Spectrometry Liquid Chromatography-Mass Spectrometry Principal Component Analysis Spectra Fluorescence Signature EXTRACTS Withania somnifera Bacopa monnieri Centella asiatica
• 年，卷（期）: 2020,（9）
• 页码范围: 80-98
• 页数: 19页
• 分类号: R74

摘要

Spectral fluorescence signature, Gas Chromatography-Mass Spectrometry and Liquid Chromatography-Mass Spectrometry for identification of chemical and bioactive compounds were applied to study the plant extracts of <em>Withania somnifera</em>, <em>Centella asiatica </em>and <em>Bacopa monnieri </em>which are related to the possible treatment of mental diseases as Alzheimer, Parkinson and Depression. These plants are known for different positive phytotherapeutic effects on the human brain without negative post-, adverse or after effects to the treated individuals, and have been recommended in several medical studies. Therefore, we selected these plants for further analysis, based on the inhibition results of <em>in vitro</em> Amyloid Beta fibrillation tests made by previous measurements. With this study a first screening of the complex plant extract mixtures was performed, to get an initial overview about known and unknown ingredients. In all three plants, similar main compounds were identified, however in different quality and quantity. These may provide substantial information on which compound combinations might be mainly responsible for the positive effects and should be further investigated being responsible for reducing the fibrillation process of Amyloid Beta.