Biocompatibility of polyetheretherketone for the treatment of orbital bone defects

• 作者: Fan Xiao Kai-Jian Sun Lin Wang Lin-Lin Chen Rui-Dong Gu
• 来源期刊: 国际眼科杂志:英文版
• 学科: 工学
• 关键词: POLYETHERETHERKETONE HISTOCOMPATIBILITY orbital defect orbital burst fracture three-dimensional printing RABBIT
• 年，卷（期）: 2020,（5）
• 页码范围: 725-730
• 页数: 6页
• 分类号: TQ3

摘要

AIM: To investigate the biocompatibility and therapeutic effects of polyetheretherketone(PEEK) on recovery of a rabbit orbital defect.METHODS: Totally 16 New Zealand rabbits were used to establish an orbital bone defect model and then randomly divided into two groups. PEEK was implanted in the experimental group. The control group was blank, and no substance was implanted. The model rabbits were sacrificed at 4 and 8 wk, and examined by general observations, histology, electron microscopy, Western blotting, and realtime polymerase chain reaction.RESULTS: No infection or rejection occurred after PEEK implantation, and biocompatibility was good. The relative expression of vascular endothelial growth factor(VEGF) protein in the experimental group was significantly higher than that in the control group postoperatively(P<0.05). Bone defect repair in the experimental group was significantly better than that in the control group in the same period and some osteogenesis was observed.CONCLUSION: PEEK has good biocompatibility and efficacy for the treatment of orbital bone defects in a rabbit model.