Pulmonary alveolar regeneration in adult COVID-19 patients

• 作者: Huijuan Wu Jingyu Chen Nan Tang Yuanyuan Yu
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2020,（8）
• 页码范围: 708-710
• 页数: 3页
• 语种: 英文

摘要

Dear Editor, Alveolar regeneration after an acute lung injury has been observed in many mammals.Results in animal models have shown that alveolar type Ⅱ (AT2) cells function as resident alveolar stem cells that can proliferate and differentiate into alveolar type Ⅰ (AT1)cells to build new alveoli after lung injury.1 However, alveolarregeneration after acute lung injury in adult humans is still poorly characterized, mainly due to the lack of lung samples and regeneration-specific molecular markers.In patients with COVID-19 pneumonia, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly attack alveolar epithelial cells and cause massive AT2 cell death.It is unknown whether alveolar regeneration occurs upon SARS-CoV-2 infection-induced lung injury.This knowledge will substantially improve our basic understanding of the COVID-19 disease and our ability to prognosticate patient outcomes.