Effects of Liuwei Dihuang Decoction (Yukmijihwang-tang) on Physical Fatigue by Regulating Neurotransmitters in Brain

• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2020,（11）
• 所属期刊栏目: Original Articles
• 页码范围: 839-844
• 页数: 6页
• 语种: 英文
• DOI: 10.1007/s11655-019-3157-9

摘要

Objective:To study the effect of Liuwei Dihuang Decoction(六味地黄汤) or Yukmijihwangtang (YJT) on endurance exercise by in vivo experiment.Methods:ICR mice were randomly divided into the control group (distilled water) and the YJT groups (1,10,100 mg/kg),5 animals per group.YJT and distilled water were orally administered.The anti-fatigue effect of YJT was evaluated by open filed test (OFT),forced swimming test (FST),and tail suspension test (TST).Results:In the OFT,YJT significantly increased the total movement distance in a dose-dependent manner.Additionally,treatment with YJT significantly decreased immobility time in the FST and the TST.Various neurotransmitters such as norepinephrine (NE),serotonin(5-HT),dopamine (DA) levels were increased by FST.Administration of YJT down-regulated the expression levels of NE,5-HT,5-hydroxyindole-acetic acid (5-HIAA),and DA in the brain stem and hypothalamus of mice.Moreover,protein expression of HSP70 in mice liver and heart muscles was significantly increased in the YJT groups.Conclusion:YJT could ameliorate fatigue and enhance exercise tolerance through suppressing of brain monoamines including NE,5-HT,5-HIAA,and DA in FST mice model.