Anti-inflammatory signaling through G protein-coupled receptors

• 来源期刊: 中国药理学报（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Review Article
• 页码范围: 1531-1538
• 页数: 8页
• 语种: 英文

摘要

G protein-coupled receptors (GPCRs) play important roles in human physiology.GPCRs are involved in immunoregulation including regulation of the inflammatory response.Chemotaxis of phagocytes and lymphocytes is mediated to a great extent by the GPCRs for chemoattractants including myriads of chemokines.Accumulation and activation of phagocytes at the site of inflammation contribute to local inflammatory response.A handful of GPCRs have been found to transduce anti-inflammatory signals that promote resolution of inflammation.These GPCRs interact with selected metabolites of arachdonic acid,such as lipoxins,and of omega-3 essential fatty acids,such as resolvins and protectins.Despite mounting evidence for the in vivo functions of these antiinflammatory and pro-resolving ligands paired with their respective GPCRs,the underlying signaling mechanisms have not been fully delineated.The present review summarizes what we have learned about these GPCRs,their structures and signaling pathways and the prospect of targeting these receptors for novel anti-inflammatory therapies.