Single vs. Double Dose Iron Supplementation for Prevention of Iron Deficiency Anemia in Twin Pregnancy: A Randomized Controlled Clinical Trial

• 作者: Ahmed Mohammed Abbas Khaled Afifi Khaled Ibrahim Manal Mahmoud Elhalwagy Mohamed Samir Sweed
• 来源期刊: 妇产科期刊(英文)
• 学科: 数学
• 关键词: Iron Supplementation Iron Deficiency Anemia Twin Pregnancy HEPCIDIN Mucosal Block
• 年，卷（期）: 2020,（12）
• 页码范围: 1788-1802
• 页数: 15页
• 分类号: O17

摘要

<b><span style="font-family:Verdana;">Introduction: </span></b><span style="font-family:Verdana;">It is estimated that about 18% of pregnant women suffer from iron deficiency anemia throughout their whole pregnancy.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">In </span><span style="font-family:Verdana;">twin</span><span style="font-family:Verdana;"> pregnancy, owing to the relatively greater </span><span style="font-family:Verdana;">feto-placental</span><span style="font-family:Verdana;"> requirements and greater expansion in maternal plasma volume </span></span><span style="font-family:Verdana;">and red cell mass, iron requirements </span><span style="font-family:""><span style="font-family:Verdana;">are magnified 1.8 times compared to singleton pregnancies. However, for </span><span style="font-family:Verdana;">prevention</span><span style="font-family:Verdana;"> of iron deficiency in twin </span><span style="font-family:Verdana;">pregnancy</span><span style="font-family:Verdana;">, only sparse data exist regarding the sufficiency of the standard antenatal iron supplementation dose used in singleton pregnancies to meet the increased iron demand. In this study, we investigate the effect of single and double dose iron supplementation for </span><span style="font-family:Verdana;">prevention</span><span style="font-family:Verdana;"> of iron deficiency anemia in twin pregnancy. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">A randomized controlled clinical trial was conducted at our center in the period between February 2019 and October 2020,</span></span><span style="font-family:Verdana;"> and</span><span style="font-family:""> <span style="font-family:Verdana;">included</span><span style="font-family:Verdana;"> 450 eligible healthy non-anemic women aged 18 </span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 35 years, with twin pregnancy at 12 </span><span style=