Recent advances in nickel-catalyzed reductive hydroalkylation and hydroarylation of electronically unbiased alkenes

• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2020,（11）
• 所属期刊栏目: MINI REVIEWS
• 页码范围: 1586-1600
• 页数: 15页
• 语种: 英文

摘要

The use of simple and easily available feedstock to quickly and efficiently obtain compounds with complex molecular structures through the transition-metal-catalyzed construction of C(sp3)-C bonds has important significance.As traditional C(sp3)-C coupling reagents,alkylmetallic reagents often have limitations such as air and moisture sensitivity and difficulties in storage.Nickel-catalyzed reductive olefin hydrocarbonation reactions use alkenes to replace organometallic reagents,reduce the synthesis steps,improve the functional group compatibility,and expand the substrate scope.This minireview discusses important progress in the hydroalkylation and hydroarylation of electronically unbiased alkenes in recent years and describes the key mechanism and applications.