IRP2-Hif1α/Hif2α signaling: a novel mechanism of metabolic switch from aerobic glycolysis to oxidative phosphorylation

• 来源期刊: 生物化学与生物物理学报（英文版）
• 年，卷（期）: 2020,（10）
• 所属期刊栏目: Research Highlights
• 页码范围: 1175-1177
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/abbs/gmaa088

摘要

Iron regulatory protein 2 (IRP2), first separated from mouse in 1993, is a cytoplasmic iron-regulated RNA-binding protein.IRP2 is a subtype of iron regulatory proteins (IRPs).IRP2 binds to ironresponsive element (IRE) RNA sequence to maintain iron homeostasis [1].IRP2 can easily be hydrolyzed by protease because of its unique sequence of 73 amino acids.In general, IRP2 is widely expressed in many tissues, including fat, lung, brain, stomach, liver, heart, thyroid, adrenal, lymph node, kidney, intestine and so on [2].