Self-Assembly of Amyloid-Beta and Its Piezoelectric Properties

• 作者: Ivonne Rosales Laura Salazar Daniel Luna Alicia Negrón Igor Bdikin Brian J. Rodriguez Alejandro Heredia
• 来源期刊: 美国分子生物学期刊(英文)
• 学科: 医学
• 关键词: AMYLOID Neurodegenerative Disorders SELF-ASSEMBLY PIEZOELECTRICITY
• 年，卷（期）: 2021,（1）
• 页码范围: 1-14
• 页数: 14页
• 分类号: R74

摘要

Investigating amyloid nanofibril self-assembly, with an emphasis on the electromechanical property of amyloid peptides, namely, piezoelectricity, may have several important implications: 1) the self-assembly process can hinder the biological stability and give rise to the formation of amyloid structures associated with neurodegenerative diseases;2) investigations in this field may lead to an improved understanding of high-performance, functional biological nanomaterials, 3) new technologies could be established based on peptide self-assembly and the resultant functional properties, e.g., in the creation of a piezoelectric device formed with vertical diphenylalanine peptide tubes as a piezoelectric biosensor, and 4) new knowledge can be generated about neurodegenerative disorders, potentially yielding new therapies. Therefore, in this review, we will present the current investigations associated with self-assembly of amyloid-beta, the mechanisms that generate new structures, as well as theoretical calculations exploring the functionality of the structures under physiological pressure and electric field.