Cystatin C Peptide Effects on B16F10 Melanoma Cells

• 作者: Mathieu Hill James L. Cox
• 来源期刊: 细胞生物学(英文)
• 学科: 医学
• 关键词: CYSTATIN PEPTIDE MELANOMA METASTASIS
• 年，卷（期）: xbswxyw_2021,（1）
• 页码范围: 1-9
• 页数: 9页
• 分类号: R73

摘要

<strong>Background</strong>: Metastasis is a major problem for effective therapy of cancer. Small cysteine protease inhibitors, cystatins have been shown to be anti-metastatic for a number of different cancers. We have identified a small peptide of cystatin which exhibits anti-cancer properties for B16 melanoma cells in vitro. <strong>Methods</strong>: B16 melanoma cells were measured for growth, proliferation, migration, and apoptosis in the presence and absence of cystatin peptide. <strong>Results</strong>: The cystatin peptide reduced melanoma cell growth, proliferation, migration, and increased apoptosis in melanoma cells in culture. <strong>Conclusion</strong>: Cystatin peptide exhibits anti-cancer effects on highly metastatic B16 melanoma cells in culture.