SARS-CoV-2-induced lung pathology:AHR as a candidate therapeutic target

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: RESEARCH HIGHLIGHTS
• 页码范围: 1-2
• 页数: 2页
• 语种: 英文

摘要

The aryl hydrocarbon receptor(AHR)is activated by multiple viruses to evade the host immune response,a strategy exploited in pre-clinical models to limit the replication of Zika and Influenza A.In a recent study,Liu et al.report that AHR drives the hypersecretion of lung mucins after SARS-CoV-2 infection,suggesting a role for AHR in respiratory failure and highlighting its potential therapeutic value.