Metal Complexes with 8-Hydroxyquinoline: Synthesis and <i>In Vitro</i>Antimicrobial Activity

• 作者: Amira Cipurković Emir Horozić Snjež ana Marić Lejla Mekić Halid Junuzović
• 来源期刊: 应用科学(英文)
• 学科: 化学
• 关键词: 8-HQ Metal Complex Antimicrobial Activity In Vitro Study
• 年，卷（期）: 2021,（1）
• 页码范围: 1-10
• 页数: 10页
• 分类号: O62

摘要

In this paper, three complexes with 8-hydroxyquinoline (8-HQ) were synthesized, their spectral analysis was performed and the antimicrobial effect was examined <em>in vitro</em>. The stoichiometric ratio of the complex was determined conductometrically and spectrophotometrically. FTIR and UV/VIS spectroscopy were used for structural characterization. Antimicrobial activity was examined by diffusion technique on selected gram-positive and gram-negative bacteria, and<em> C. albicans</em>. Square planar and octahedral geometry complexes were synthesized by mixing in a molar ratio of 1:2 (M:L). Based on the spectral data, it is concluded that both oxygen and nitrogen atoms from 8-HQ are involved in the formation of the complex. The antimicrobial activity of the complexes is high, with zones of inhibition in the range of 15 - 28 mm. 8-HQ was shown to have a significantly higher ability to inhibit the growth of the tested microorganisms.