Cutaneous Hypersensitivity as an Indicator of Visceral Inflammation via C-Nociceptor Axon Bifurcation

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Original Articles
• 页码范围: 45-54
• 页数: 10页
• 语种: 英文

摘要

Pain on the body surface can accompany disor-ders in the deep tissue or internal organs.However,the anatomical and physiological mechanisms are obscure.Here,we provided direct evidence of axon bifurcation in primary C-nociceptive neurons that innervate both the skin and a visceral organ.Double-labeled dorsal root ganglion(DRG)neurons and Evans blue extravasation were observed in 3 types of chemically-induced visceral inflam-mation(colitis,urocystitis,and acute gastritis)rat models.In the colitis model,mechanical hypersensitivity and spontaneous activity were recorded in vivo from double-labeled C-nociceptive neurons in S1 or L6 DRGs.These neurons showed significantly enhanced responses to both somatic stimulation and colorectal distension.Our findings suggest that the branching of C-nociceptor axons con-tribute to cutaneous hypersensitivity in visceral inflamma-tion.Cutaneous hypersensitivity on certain locations of the body surface might serve as an indicator of pathological conditions in the corresponding visceral organ.