Post-Acute Sequelae of SARS-Cov-2 Infection Associating Peripheral, Autonomic and Central Nervous System Disturbances: Case Report and Review of the Literature

• 作者: David S. Younger
• 来源期刊: 神经科学国际期刊(英文)
• 学科: 数学
• 关键词: COVID-19 SARS-CoV-2 Long Hauler Long Covid Peripheral Neuropathy DYSAUTONOMIA Encephalopathy ENCEPHALITIS EMG NCS Tilt Table Test Epidermal Nerve Fibers PET/MRI
• 年，卷（期）: 2021,（1）
• 页码范围: 17-21
• 页数: 5页
• 分类号: O17

摘要

<strong>Aim</strong><span><span><span style="font-family:;" "=""><strong>:</strong> To describe post-infectious neurological aspects of COVID-19 in a patient with progressive post-infectious peripheral (PNS), autonomic (ANS) and central nervous system (CNS) involvement due to SARS-CoV-2 infection. <b>Background</b> <b>and</b> <b><strong>Purpose</strong></b><strong>:</strong> A variety of neurological manifestations have been described in association with Covid-19, however</span></span></span><span><span><span style="font-family:;" "="">,</span></span></span><span><span><span style="font-family:;" "=""> progressive multisystem neurological aspects have not been described. <b><strong>Methods</strong></b><strong>:</strong> A case report detailing the history, examination, and infectious serology associated with SARS-CoV-2, and subsequent neurodiagnostic laboratory testing and treatment. <b><strong>Results</strong></b><strong>:</strong> Neurodiagnostic laboratory studies showed large-fiber demyelinating sensorimotor and painful small fiber sensory polyneuropathy, orthostatic hypotension, and hypometabolism of bilateral anterior and mesial temporal lobes with a possible frontal seizure focus. Treatment was initiated with high-dose immune globulin therapy. <b><strong>Conclusions</strong></b><strong>:</strong> The combination of PNS, ANS <span>and</span> CNS involvement in this patient was associated with post-infectious acquired immunity to SARS-CoV-2.</span></span></span>