3-(Tetrazol-5-yl)-2-imino-coumarins Derivatives: Synthesis, Characterization, and Evaluation on Tumor Cell Lines

• 作者: Ali Bouattour Mehdi Fakhfakh Souhir Abid El-Gharbi Majdi Abid Ludovic Paquin Rémy Le Guevel Thierry Charlier Houcine Ammar Jean-Pierre Bazureau
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: 2-Iminocoumarin TETRAZOLE FLUORESCENCE Tumor Cell Lines HCT 116
• 年，卷（期）: yjhxgjqkyw_2021,（1）
• 页码范围: 24-34
• 页数: 11页
• 分类号: O62

摘要

The first report of new 3-(tetrazol-5-yl)-2-iminocoumarin derivatives is described. The title compounds were prepared in two steps and were obtained in good yields (55-93%). They have been fully characterized by ¹H, ¹³C NMR, FTIR, UV-Visible and HRMS. They were tested for their antiproliferative activities against six representative human tumor cell lines (Huh 7-D12, Caco2, MDA-MB231, HCT 116, PC3 and NCI-H727) and HaCat keratinocytes. Among them, compound 5e was active on HCT 116 (IC₅₀ 15 μM).