Areview of the prescription containingHirudo for diabeticnephropathy

• 作者: Jun-Lin Mo Chun-Li Long wei Shi Jue-Ying Chen Yong-Xiang Xie
• 来源期刊: 药物联合治疗
• 学科: 医学
• 关键词: HIRUDO Diabetic nephropathy Modern literature Medication rule Data mining
• 年，卷（期）: 2021,（1）
• 页码范围: 42-51
• 页数: 10页
• 分类号: R28

摘要

Background:Based on the modern literature,this paper discusses the characteristics of the medication and the prescription rules of the prescriptions containing Shuizhi(Hirudo)for diabetic nephropathy.Methods:We searched the China National Knowledge Infrastructure Database,Wanfang Academic Journals Full-text Database,VIP Chinese Journals Database and China Biomedical Literature Database,as well as Pubmed,the Cochrane Library and EMbase.The time limit is from setup time to November 4,2020.Include literatures published in journals containing prescriptions for treating diabetic nephropathy with Hirudo.These data was established a standardized database and then mined these data using association rules,improved mutual information method,complex system entropy clustering and other mining methods with traditional Chinese medicine inheritance auxiliary system(V2.5)software to excavate the characteristics of medication and the rules of prescription.Results:The study finally included 477 literatures,involving 477 prescriptions,235 Chinese medicines,5,552 times of total medicine frequency,and unearthed 20 core formulas and 9 new formula combinations.Among them,high-frequency drugs are Hirudo,HuangQi(Astragali radix),Danshen(Salviae miltiorrhizae radix et rhizoma),Shanyao(Dioscoreae rhizoma),Dahuang(Rhei radix et rhizoma),Shanzhuyu(Corni fructus),Fuli(Poria),Danggui(Angelicae sinensis radix),Shengdihuang(Rehmanniae radix),Chuanxiong(Chuanxiong rhiazoma)et al.The core prescription is a combination of Astragali radix,Hirudo,Dioscoreae rhizoma,Poria,Corni fructus,Angelicae sinensis radix,et al.Conclusion:High-frequency drugs and core prescriptions embody the characteristics of“Replenishing Qi”,“Activating Blood”,and“Nourishing Yin”.The core prescription rules were“Replenishing Qi”and“Activating Blood”.Promoting the circulation of“Qi”,promoting“Urination and Draining”,“Downbearing”the turbid were the auxiliary functions.The unearthed new prescriptions provide new ideas for the combination of prescr