<i>In Vivo</i>Evaluation of Anti-Mycobacterial Activity of a Phytomedicine “MATHESIA” on <i>Mycobacterium ulcerans</i>: Influence of Alkalinity on the Activity of Antibiotics Used in the Treatment of Buruli Ulcer

• 作者: L. H. Nkasa K. J. Kadinekene O. Kiabanzawoko B. Tchey S. Kimbonza M. O. Lunguya S. S. Karhemere Bin M. C. Mulenga T. J. J. Muyembe S. J. Kayembe K. M. Taba
• 来源期刊: 医学微生物学(英文)
• 学科: 数学
• 关键词: Buruli Ulcer Mycobacterium ulcerans Mathesia ETHANOLAMINE RIFAMPICIN ETHAMBUTOL Isoniazid Kibadi Solution
• 年，卷（期）: 2021,（1）
• 页码范围: 47-57
• 页数: 11页
• 分类号: O17

摘要

<span style="font-family:""><span style="font-family:Verdana;">T</span><span><span style="font-family:Verdana;">he present study reports the </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> anti-Mycobacterial Activity of a Phytomedicine </span></span></span><span style="font-family:Verdana;">“</span><span style="font-family:Verdana;">MATHESIA</span><span style="font-family:Verdana;">”</span><span style="font-family:""><span style="font-family:Verdana;"> on </span><i><span style="font-family:Verdana;">Mycobacterium ulcerans</span></i><span style="font-family:Verdana;">. It also explores the influence of ethanolamine (alkali agent) on the </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> activity of some antibiotics (Isoniazid, Rifampicin, Ethambutol) used in the treatment of Buruli ulcers in DR Congo. Experiments were conducted on adult white Wistar rats of both sex</span></span><span style="font-family:Verdana;">es</span><span style="font-family:Verdana;"> with the weights comprising between 110</span><span style="font-family:Verdana;"> - </span><span style="font-family:Verdana;">165</span><span style="font-family:""> </span><span style="font-family:Verdana;">g.</span><span style="font-family:""> </span><span style="font-family:Verdana;">The result obtained have show</span><span style="font-family:Verdana;">n</span><span style="font-family:""><span style="font-family:Verdana;"> that the phytomedicine MATHESIA (pH 10) has a good </span><i><span style="font-family:Verdana;">in vivo </span></i><span style="font-family:Verdana;">activity on </span><i><span style="font-family:Verdana;">M. ulcerans</span></i><span style="font-family:Verdana;"> and the duration for wounds healing and total cicatrization was 6 days;whereas this duration was 10, 12, 14, and 16 days respectively</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">for Rifampicin (IV, pH 10), Kibadi</span><span style="font-fa