Mesenteric traction syndrome in pigs: A single- blinded, randomized controlled trial

• 作者: Rune B.Strandby Jens T.F.Osterkamp Rikard Ambrus Amelie Henriksen Jens P.Goetze Niels H.Secher Michael P.Achiam Lars-Bo Svendsen
• 来源期刊: 动物模型与实验医学（英文）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Original Articles
• 页码范围: 162-168
• 页数: 7页
• 语种: 英文
• DOI: 10.1002/ame2.12160

摘要

Background : Mesenteric traction syndrome is commonly observed in patients undergoing upper abdominal surgery and is associated with severe postoperative complications. A triad of hypotension, tachycardia, and facial flushing seems provoked by prostacyclin (PGI 2 ) release from the gut in response to mesenteric traction. The administration of nonsteroidal anti-i nflammatory drugs (NSAID) inhibits PGI 2 release, stabilizing the hemodynamic response. Here, we examined the effect of mesenteric traction on splanchnic blood flow in pigs randomized to NSAID or placebo treatment. Materials and Methods : Twenty pigs were allocated to either ketorolac or pla-cebo treatment. Five minutes of manual mesenteric traction was applied. Plasma 6- keto- PGF1 , a stable metabolite of PGI 2 , hemodynamic variables, and regional blood flow (laser speckle contrast imaging) to the liver, stomach, small intestine, upper lip, and snout (laser Doppler flowmetry) were recorded prior to traction and 5 and 30 minutes thereafter.Results : Both groups of pigs presented a decrease in systemic vascular resistance ( P .01), mean arterial blood pressure ( P .001), and blood flow in the gastric an-trum ( P .002). Plasma 6- keto- PGF1 did not increase in either group ( P .195), and cardiac output, heart rate, central venous pressure, and blood flow to the liver, small intestine, upper lip, and snout remained unchanged. Conclusion : Mesenteric traction resulted in cardiovascular depression, including re-duced blood flow in the gastric antrum. Plasma 6- keto- PGF1 did not increase, and ketorolac administration did not alter the response to mesenteric traction. Furthers studies are needed to identify which substance is responsible for eliciting the cardio-vascular response to mesenteric traction in pigs.