Is There a Relationship between Endotheline-1, Vascular Cell Adhesion Molecule-1 and the Arterial Hypotension Observed during Spinal Anesthesia?

• 作者: J. F. Nnang Essone K. Nzé Pascal G. Edjo Nkhilli N. Ekegue Diaw Mor C. P. Akagha Kondé P. Nzoghe Nguéma E. Anyunzok E. R. Obame C. Allognon B. Nguéma Asseko F. Ovono Abessolo E. Ngou Milama
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: ENDOTHELIN-1 VCAM-1 HYPOTENSION Endothelial DYSFUNCTION Spinal ANESTHESIA
• 年，卷（期）: 2021,（1）
• 页码范围: 64-85
• 页数: 22页
• 分类号: R61

摘要

<strong>Introduction:</strong> The involvement of the endothelial dysfunction (ED) in arterial hypotension (AHPT) post of spinal anesthesia (SA) has not been established. <strong>Objective: </strong>To determine if there is a relationship between ED and AHPT observed during the 1st 15 minutes after SA. <strong>Population and Methods:</strong> The study concerned 40 people who were to benefit from a programmed herniorrhaphy under SA and 40 controls (SA^-). The correlations between mean plasma concentrations of endothelin-1 (CmET-1, pg/ml) and Vascular Cell Adhesion Molecule-1 (CmVCAM-1, pg/ml) taken from SA⁺ one hour before (H0), then 15 minutes after the SA (H15) and the mean arterial pression (AMP, mmHg) with heart rate (bpm) were analyzed (p < 5%). <strong>Results:</strong> CmET-1 and CmVCAM-1 of SA^- were 1.07 and 3.34, respectively, compared to 1.12 (p = 0.735) and 3.57 (p = 0.862) in SA⁺ at H0 and H15. In SA+, at H15, CmET-1 was 1.13 (p = 0.823) and CmVCAM-1 was 3.57 (p = 0.257). In SA^-, a negative correlation existed between CmET-1 and CmVCAM-1 (r = -0.438;p = 0.005). Conversely, in SA⁺, whether at H0 (r = -0.31;p = 0.051) or at H15 (r = 0.024;p = 0.883), no correlation existed between CmET-1 and CmVCAM-1, nor between MAP and ED markers (r = 0.111;p = 0.325). <strong>Conclusion: </strong>These results show that there is no relationship between the AHPT which occurs during the first fifteen minutes post SA, CmVCAM-1 and CmET-1. Moreover, these data suggest that ED is not involved in AHPT post SA.