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<em>Dioscorea</em><span style="font-family:;" "=""><span style="font-family:Verdana;"> spp., White Yam has been shown to exhibit a wide range of nutritional and medicinal properties. However, the compounds associated with its medicinal functions have not been fully examined. The purpose of this study was to generate a chemoinformatic profile of the bioactive compounds present in </span><i><span style="font-family:Verdana;">Dioscorea</span></i><span style="font-family:Verdana;">. </span><i><span style="font-family:Verdana;">alata</span></i><span style="font-family:Verdana;"> (</span><i><span style="font-family:Verdana;">D</span></i><span style="font-family:Verdana;">. </span><i><span style="font-family:Verdana;">alata</span></i><span style="font-family:Verdana;">) and to characterize their putative anti-cancer properties using prostate (DU145) and lung (A549) cancer cells. Chemoinformatic profiling of </span><i><span style="font-family:Verdana;">D</span></i><span style="font-family:Verdana;">. </span><i><span style="font-family:Verdana;">alata</span></i><span style="font-family:Verdana;"> resulted in five bioactive extracts</span></span><span style="font-family:Verdana;">:</span><span style="font-family:Verdana;"> hexane (DaJa-1), ether (DaJa-2), acetone (DaJa-3), ethanol (DaJa-4) and water (DaJa-5) were generated. The analytes present in the five bioactive extracts were dissolved in 0.1% DMSO and their anti-cancer activity </span><span style="font-family:Verdana;">were </span><span style="font-family:Verdana;">determined. We observed that the acetone extract (DaJa3) was the only extract capable of inducing greater tha</span><span style="font-family:Verdana;">n</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> 90% cell death of DU 145 cell at 100 μg/mL. The order of growth inhibition of the extracts in DU-145 cell is DaJa-3 (IC50, 31.45 μg/mL) > DaJa-4 (IC50 60 μg/mL) > DaJa-1 (IC50 > 100 μg/mL) ≥ DaJa-2 (IC50 > 100 μg/mL) ≥ DaJa-5 (IC50 > 100 μg/mL). MTT cell viability, dye excl
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篇名 Acetone Extract of &lt;i&gt;Dioscorea alata&lt;/i&gt;Inhibits Cell Proliferation in Cancer Cells
来源期刊 美国植物学期刊(英文) 学科 医学
关键词 Dioscorea alata Acetone Extract Anticancer Activity White Yam
年,卷(期) mgzwxqkyw_2021,(3) 所属期刊栏目
研究方向 页码范围 300-314
页数 15页 分类号 R73
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研究主题发展历程
节点文献
Dioscorea
alata
Acetone
Extract
Anticancer
Activity
White
Yam
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
美国植物学期刊(英文)
月刊
2158-2742
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
1814
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0
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