Prevalence of Cardiovascular Risk Factors and Heterozygous Familial Hypercholesterolemia in Premature Atherosclerotic Patients Presenting with Acute Coronary Syndrome

• 作者: Ahmed Ashraf Reda Mahmoud Ali Soliman Ahmed Mokhtar Elkersh Sabry Rasmy Yousef
• 来源期刊: 心血管病(英文)
• 学科: 医学
• 关键词: Acute Coronary Syndrome Heterozygous Familial
• 年，卷（期）: xxgbyw_2021,（3）
• 页码范围: 195-209
• 页数: 15页
• 分类号: R54

摘要

<strong>Background:</strong><span style="font-family:Verdana;"> Heterozygous familial hypercholesterolemia is an autosomal dominant genetic disorder with an estimated prevalence of 1/200</span><span style="font-family:Verdana;"> - </span><span style="font-family:;" "=""><span style="font-family:Verdana;">1/500 in the general population. Early identification of patient with familial hypercholesterolemia is important, because appropriate treatment may reduce the risk of premature atherosclerosis.</span><b><span style="font-family:Verdana;"> Objective:</span></b><span style="font-family:Verdana;"> Assessment of the prevalence of different modifiable cardiovascular risk factors and clinical diagnosis of heterozygous familial hypercholesterolemia.</span></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;"><b>Methods: </b></span><span style="font-family:;" "=""><span style="font-family:Verdana;">One hundred patients were enrolled, included young patients (males less than 50 years and females less than 60 years old) presented with first attack of acute coronary syndrome either ST elevation myocardial infarction (STEMI), non ST elevation myocardial infarction (NSTEMI) or unstable angina (UA). All patients were subjected to full history taking, general and local examination, Electrocardiogram, transthoracic Echocardiography, laboratory investigations, coronary angiography and Dutch score calculation for familial hyperlipidemias. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The mean level of serum cholesterol among studied group was 268.31</span></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">±</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">59.33, HDL-C was 39.63</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">±</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">7.52, LDL was 192.27</span><span