Objective: To review the published literature related to the different obliteration and reconstruction techniques in the management of the canal wall down mastoidectomy.Methods: A PubMed (Medline) and LILACS databases as well as crossed references search was performed with the following Mesh terms:"cholesteatoma","cholesteatoma-middle ear","otitis media","otitis media, suppurative","mastoiditis","mastoidectomy","canal wall down mastoidectomy","radical mas-toidectomy","mastoid obliteration"and crossed references. Inclusion criteria were adult patients subject to mastoid cavity obliteration and posterior canal wall reconstruction. The technique and materials used, anatomic and functional results, complications, recurrence rates, and changes in quality of life, were analyzed. A total of 94 articles were screened, 38 were included for full-text detailed review. Results: Twenty-one articles fulfilled the inclusion criteria. Techniques and materials used for canal wall reconstruction, tympanoplasty, and ossiculoplasty were varied and included autologous, biosynthetic, or both. Auditory results were reported in 16 studies and were inconsistent. Three studies reported improvement in the quality of life using the GBI scale. Follow-up time ranged from 1 to 83 months. Eleven articles used imaging studies to evaluate postoperative disease recurrence. The highest recurrence rate reported for cholesteatoma after obliteration was 19%. The most frequently reported complications were retraction pockets and transient otorrhea. Conclusion: Plenty of techniques combining grafts and other materials have been used to overcome mastoidectomy cavity problems. So far, it is still not possible to standardize an ideal procedure. The available level of evidence for this topic is low and limited.