The nuclear bodies formed by histone demethylase KDM7A

• 作者: Hui Ming Qianfeng Wang Yuwen Zhang Luzhang Ji Lu Cheng Xiangru Huo Zixiang Yan Zhexiao Liu Yongjun Dang Bo Wen
• 来源期刊: 蛋白质与细胞
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: LETTERS
• 页码范围: 297-304
• 页数: 8页
• 语种: 英文

摘要

Dear Editor, In the nucleus of higher eukaryotes, chromatin occupies only a small proportion of the nuclear space, while many proteins and RNAs segregate into membrane-less nuclear bodies (NBs).These NBs follow a stochastic or ordered assembly model and constantly exchange components with the surrounding nucleoplasm (Jain et al., 2016).Typical NBs include nucleoli, nuclear speckles, paraspeckles, PML bodies, Cajal bodies, polycomb bodies and Sam68 bodies,which play critical roles in various biological processes such as ribosome assembly, RNA processing, and protein modification.The dysfunction of nuclear bodies may cause diseases, such as cancer (Li et al., 2019).