Mapping the Brain-Wide Cholinergic Neurons Projecting to Skeletal Muscle in Mice by High-Throughput Light Sheet Tomography

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 267-270
• 页数: 4页
• 语种: 英文

摘要

Dear Editor, The cholinergic system plays an important role in regulat-ing locomotion and motor functions by modulating neu-ronal activity[1].However,the anatomical relationships between the brain-wide cholinergic system and skeletal muscles remain unclear.To understand how this system modulates the activity of skeletal muscles,details of the pattern of cholinergic innervation and differences in the innervation of skeletal muscles are necessary.However,classical immunohistochemical methods are unable to test unequivocally whether a mapping exists in the connections from the brain to skeletal muscles.