Adding Fuel to the Fire by Increased GABAergic Inhibition:A Seizure-Amplifying Nigra-Parafascicular Pathway

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Research Highlights
• 页码范围: 135-137
• 页数: 3页
• 语种: 英文

摘要

Epilepsy is a common neurological disorder characterized by recurrent seizures.Most antiepileptic drugs(AEDs)work by regulating the balance of the excitatory gluta-matergic and inhibitory GABAergic transmission.How-ever,the current AEDs cannot successfully control seizures in most(＞70％)patients with temporal lobe epilepsy(TLE)[1],in whom seizures typically begin in the hippocampus.