Modeling the Degradation Effects of Autophagosome Tethering Compounds

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 255-260
• 页数: 6页
• 语种: 英文

摘要

Dear Editor, The selective degradation of specific pathogenic proteins provides exciting strategies for drug discovery.Emerging new concepts such as proteolysis-targeting chimeras and autophagosome-tethering compounds(ATTECs)are based on the design of"molecular glues"or bifunctional chimeric compounds that tether the target protein(protein of interest,POI)to a specific component of the protein-degradation machinery(PDM)[1-3].