Functionalized graphene oxide nanosheets with unique three-in-one properties for efficient and tunable antibacterial applications

• 作者: Bo-Yao Lu Guan-Yin Zhu Chen-Hao Yu Ge-Yun Chen Chao-Liang Zhang Xin Zeng Qian-Ming Chen Qiang Peng
• 来源期刊: 纳米研究（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Research Articles
• 页码范围: 185-190
• 页数: 6页
• 语种: 英文

摘要

Developing antibiotics-independent antibacterial agents is of great importance since antibiotic therapy faces great challenges from drug resistance.Graphene oxide(GO)is a promising agent due to its natural antibacterial mechanisms,such as sharp edge-mediated cutting effect.However,the antibacterial activity of GO is limited by its negative charge and low photothermal effect.Herein,the amino-functionalized GO nanosheets(AGO)with unique three-in-one properties were synthesized.Three essential properties(positive charge,strong photothermal effect,and natural cutting effect)were integrated into AGO.The positive charge(30 mV)rendered AGO a strong interaction force with model pathogen Streptococcus mutans(330 nN).The natural cutting effect of 100 μg·mL-1 AGO caused 27％loss of bacterial viability after incubation for 30 min.Most importantly,upon the near-infrared irradiation for just 5 min,the three-in-one properties of AGO caused 98％viability loss.In conclusion,the short irradiation period and the tunable antibacterial activity confer the three-in-one AGO a great potential for clinical use.