Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation

• 作者: Chuanshi He Ling Li Linlin Wang Wanrong Meng Yaying Hao Guiquan Zhu
• 来源期刊: 癌症生物学与医学（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: REVIEW
• 页码范围: 21-33
• 页数: 13页
• 语种: 英文
• DOI: 10.20892/j.issn.2095-3941.2020.0150

摘要

Radiotherapy is one of the most effective treatment methods for various solid tumors. Bidirectional signal transduction between cancer cells and stromal cells within the irradiated microenvironment is important in cancer development and treatment responsiveness. Exosomes, initially considered as "garbage bins" for unwanted from cells, are now understood to perform a variety of functions in interactions within the tumor microenvironment. Exosome-mediated regulation processes are rebuilt under the irradiation stimuli, because the exosome production, uptake, and contents are markedly modified by irradiation. In turn, irradiation-modified exosomes may modulate the cell response to irradiation through feedback regulation. Here, we review current knowledge and discuss the roles of exosome-mediated interactions between cells under radiotherapy conditions.