Fluorescence enhancement and cytotoxicity reduction of bis-viologen biphenyl by complexation of cucurbit[7]uril

• 来源期刊: 中国化学快报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Communications
• 页码范围: 725-728
• 页数: 4页
• 语种: 英文

摘要

The effect of cucurbit[7]uril (CB[7]) on fluorescence properties and biocompatibility of the bis-viologen biphenyl molecule (BPV22+) was investigated by using 1H NMR spectroscopy,fluorescence emission titration,and in vitro cytotoxicity experiments.CB[7]can be combined with BPV22+ in a stoichiometric ratio of 1:1 and 2:1.After the formation of host-guest complex,the fluorescence emission intensity of BPV22+ increased significantly,and the emission spectrum blue shifted.Meanwhile,the host-guest complexes showed better biocompatibility than BPV22+ in cell cytotoxicity studies.Results of this paper lay a foundation for the development of host-guest type of fluorescent probes,biological imaging and so forth.