Alpha-Synuclein Handling by Microglia:Activating,Combating,and Worsening

• 作者: Ning Song Leilei Chen Junxia Xie
• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: Insights
• 页码范围: 751-753
• 页数: 3页
• 语种: 英文

摘要

Neuroinflammation and α-synuclein(α-syn)aggregation are both neuropathological hallmarks of Parkinson's dis-ease(PD).Microglia are crucial participants in eliciting neuroinflammatory responses themselves,as well as mod-ulating neurotoxic activity in astrocytes,therefore forming a pathway to neurodegeneration induced by both central and peripheral insults[1,2].Microglia are supposed to express low levels of α-syn,which is physiologically functional in membrane-associated processes at the presy-naptic level in neurons.However,the cell-to-cell(prion-like)transmission of pathological proteins in neurodegen-erative diseases[3],such as α-syn in PD,prompts the investigation of α-syn handling by microglia.