Administration of Saccharomyces boulardii mafic-1701 improves feed conversion ratio, promotes antioxidant capacity, alleviates intestinal inflammation and modulates gut microbiota in weaned piglets

• 作者: Wenxiu Zhang Chengling Bao Jian Wang Jianjun Zang Yunhe Cao
• 来源期刊: 畜牧与生物技术杂志（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: ANIMAL NUTRITION AND FEEDSTUFFS
• 页码范围: 689-699
• 页数: 11页
• 语种: 英文

摘要

Background:Probiotics are used as a means to improve animal health and intestinal development. Saccharomyces boulardii is a well-known probiotic;however, few studies have examined the effects of S. boulardii on weaned piglet performance. Therefore, this 28-day study compared the effects of S. boulardii mafic-1701 and aureomycin in diets for weaned piglets on growth performance, antioxidant parameters, inflammation and intestinal microbiota. One hundred and eight piglets, weaned at 28 d of age (8.5 ± 1.1 kg), were randomly divided into the three dietary treatment groups with six pens and six piglets per pen (half male and half female). The dietary treatment groups were as follows:1) basal diet (CON);2) basal diet supplemented with 75 mg/kg aureomycin (ANT);3) basal diet supplemented with 1 × 108 CFU/kg S. boulardii mafic-1701 (SB). Results:Compared to CON group, SB group had higher feed efficiency (P<0.05) in the last 14 d and lower diarrhea rate (P< 0.05) over the entire 28 d. Total superoxide dismutase in serum was markedly increased in SB group (P<0.05). Moreover, compared with CON group, SB group decreased the levels of pro-inflammatory cytokines interleukin-6 (P< 0.01) and Tumor necrosis factor-α(P<0.05) in jejunum. Supplementation of S. boulardii mafic-1701 increased the abundance of Ruminococcaceae_UCG_009 and Turicibacter (P<0.05), whereas the abundance of unclassified_Clostridiaceae_4 was decreased (P<0.05). Furthermore, S. boulardii mafic-1701 administration increased cecal concentration of microbial metabolites, isobutyrate and valerate (P<0.05). Conclusions:The improvement in feed conversion ratio, reduction in diarrhea rate in weaned piglets provided diets supplemented with S. boulardii mafic-1701 may be associated with enhanced antioxidant activity, anti-inflammatory responses and improved intestinal microbial ecology.