Mosaic isodicentric Y chromosome harboring intact AZF region in a cryptozoospermic male with normal hormone levels

• 作者: Sheng-Yu Xie Da-Chang Tao Yuan Yang
• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: LETTER TO THE EDITOR
• 页码范围: 437-438
• 页数: 2页
• 语种: 英文
• DOI: 10.4103/aja.aja_64_20

摘要

Dear Editor, Structural aberrations of the Y chromosome,including deletions,ring chromosomes,Y-autosomal or Y-X translocations,isochromosomes,and dicentrics,occur in approximately 0.2％of live births;1 among these,partial deletion in the azoospermia factor(AZF)region of the Y chromosome is a well-characterized cause of nonobstructive severe oligozoospermia and azoospermia.2 Meanwhile,a dicentric Y chromosome,abbreviated as dic(Y),was observed to be exclusively present in males with azoospermia,suggesting more severe negative consequences of the AZF deletion for spermatogenesis.3