Study on mechanism of Radix astragali-Lithospermum erythrorhizon in treatment of diabetic ulcer based on network pharmacology

• 作者: Wei-Jing Fan Yuan-Xiang Li Hui-Min Lu Feng Xu Guo-Bin Liu
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2021,（8）
• 所属期刊栏目: Original article
• 页码范围: 25-30
• 页数: 6页
• 语种: 英文

摘要

Objective: To explore the mechanism of Radix Astragali-Lithospermum Erythrorhizon on the treatment of diabetic ulcer through the method of network pharmacology. Methods: This study included 32 compounds and 81 key targets. 100 GO functional items and 116 KEGG signal pathways were obtained by enrichment analysis. Quercetin, kaempferol, isorhamnetin, mononetin, sitosterol, ivy sapogenin and other components of astragalus-purple herb play a key role in the targets of interleukin-6, cystatin 3, vascular endothelial growth factor, epidermal growth factor receptor and mitogen-activated protein kinase 8 in diabetic ulcer, and are mainly concentrated in AGE-RAGE, TNF and other signal pathways. Results: There were 32 compounds and 81 key targets. 100 GO functional items and 116 KEGG signal pathways were obtained by enrichment analysis. Quercetin, kaempferol, isorhamnetin, mononetin, sitosterol, ivy sapogenin and other components of astragalus-purple herb play a key role in the targets of interleukin-6, cystatin 3, vascular endothelial growth factor, epidermal growth factor receptor and mitogen-activated protein kinase 8 in diabetic ulcer, and are mainly concentrated in AGE-RAGE, TNF and other signal pathways. Conclusion: Radix Astragali-Lithospermum Erythrorhizon may play the role of inhibiting inflammation, anti-apoptosis, promoting cell proliferation, angiogenesis and immune regulation through multi-components and multi-targets, and play a role in the treatment of diabetic ulcer.