Brain Macrophages:Close or Distant Relatives?

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Research Highlights
• 页码范围: 278-280
• 页数: 3页
• 语种: 英文

摘要

The concept of a mononuclear phagocyte system in which tissue-resident macrophages arise from the circulating monocytes has been dogma in immunology for more than half a century[1].While monocytes do give rise to macrophages under certain conditions,recent studies clearly demonstrate that monocytes do not primarily contribute to most adult tissue-resident macrophage pools under the steady state[2].Instead,the majority of adult tissue-resident macrophages are derived from erythro-myeloid progenitors(EMPs)in the yolk sac that seed tissue before birth[2].