Photogenerated-hole-induced rapid elimination of solid tumors by the supramolecular porphyrin photocatalyst

• 作者: Zijian Zhang Li Wang Weixu Liu Zihe Yan Yongfa Zhu Shuyun Zhou Shanyue Guan
• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2021,（5）
• 所属期刊栏目: RESEARCH ARTICLES
• 页码范围: 96-104
• 页数: 9页
• 语种: 英文
• DOI: 10.1093/nsr/nwaa155

摘要

The rapid,complete,targeted and safe treatment for tumors remains a key issue in cancer therapy.A novel treatment of solid tumors by supramolecular photocatalyst Nano-SA-TCPP with the irradiation of 600-700 nm wavelength is established.Solid tumors (100 mm3) can be eliminated within 10 min.The S0-day mouse survival rate was increased from 0％ to 100％ after the photocatalytic therapy.The breakthrough was owing to the cell membrane rupture and the cytoplasmic loss caused by photogenerated holes inside cancer cells.The porphyrin-based photocatalysts can be internalized in a targeted manner by cancer cells due to the size selection effect,without entering the normal cells.The therapy has no toxicity or side effects for normal cells and organisms.Moreover,the photocatalytic therapy is effective for a variety of cancer cell lines.Because of its high efficiency,safety and universality,the photocatalytic therapy provides us with a new lancet to conquer the tumor.