Reversion of Injured Adult Neurons to an Embryonic State by Grafts of Neural Progenitor Cells After Spinal Cord Injury

• 来源期刊: 神经科学通报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Research Highlights
• 页码范围: 271-274
• 页数: 4页
• 语种: 英文

摘要

Spinal cord injury(SCI)is a severe condition characterized by neurological dysfunction,dependence,respiratory fail-ure,psychological morbidities,and an increased mortality rate[1].Globally,its incidence ranges from 250,000 to 500,000 annually,resulting in tremendous psychological and financial burdens[1].Because of limited axonal regrowth and glial scar formation in wound healing after SCI in humans,the adult central nervous system(CNS)has very low regenerative ability,leading to permanent neu-rological impairment[2].SCI has devastating outcomes,including a high prevalence of chronic pain[3]and altered sensory function,and effective treatment is still lacking[4].