Inherently radiopaque polyurethane beads as potential multifunctional embolic agent in hepatocellular carcinoma therapy

• 作者: Wenhuan Wang Lin Sang Yiping Zhao Zhiyong Wei Min Qi Yang Li
• 来源期刊: 材料科学技术（英文版）
• 年，卷（期）: 2021,（4）
• 页码范围: 106-114
• 页数: 9页
• 语种: 英文

摘要

The aim of the current study is to report an inherently radiopaque drug-eluted beads (DEBs) as promising embolic materials for TACE techniques.Firstly,the synthesized radiopaque iodinated polycaprolactone-polyurethanes (Ⅰ-PCLUs) are synthesized by chain-extending method by using 4,4-isopropylidinedi-(2,6-diiodophenol) (IBPA) as the radiopacifying agent.Then,doxorubicin (Dox) is introduced as a chemotherapeutic agent into Ⅰ-PCLU beads via a double emulsification (W/O/W) method.The drug loading and controlled release behavior of two ratios of Ⅰ-PCLU/Dox are found to be dependent upon the internal porous microstructure,and the radiopacity is well-retained after four weeks drug release.Besides,the Ⅰ-PCLU/Dox beads exhibit positive in vitro anti-tumor effect.The in vivo intramuscular implantation and liver embolization results demonstrate that Ⅰ-PCLU beads have good histocompatibility,occlusion effect and X-ray traceability.Furthermore,the drug-loaded Ⅰ-PCLU beads are performed into a VX2 rabbit hepatocellular carcinoma (HCC) model using a micro-catheter,form embolization of hepatic arteries and inhibit the tumor growth after one week post-injection.Hence,this polymeric system provides a potential radiopaque chemoembolization candidate for HCC and other cancer therapies,which could bring opportunities to the next generation of multifunctional embolic agents.